Endothelial nitric oxide synthase and estrogen

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Endothelial nitric oxide synthase and estrogen.

See article by M.R. Andersen and S. Stender [1] (pages arginine to L-citrulline and nitric oxide (NO). Since NO 192 –199) in this issue. and citrulline are formed in equi-molar quantities, NO formation was expressed in terms of citrulline production Andersen and Stender [1] have reported regional variaper million endothelial cells. Thus it was possible to tions in endothelial nitric oxide synth...

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Membrane Estrogen Receptor Engagement Activates Endothelial Nitric Oxide Synthase

17b-Estradiol (E2) is a rapid activator of endothelial nitric oxide synthase (eNOS). The product of this activation event, NO, is a fundamental determinant of cardiovascular homeostasis. We previously demonstrated that E2-stimulated endothelial NO release can occur without an increase in cytosolic Ca. Here we demonstrate for the first time, to our knowledge, that E2 rapidly induces phosphorylat...

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Association of endothelial nitric oxide synthase gene G894T polymorphism with type two diabetes and diabetic nephropathy

Background: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) mediates a large range of processes, and abnormality in the production of NO has been implicated in diabetic complications including diabetic nephropathy (DN). G894T polymorphism in the eNOS gene has been shown to decreased activity the NO levels of plasma. The association between eNOS Glu298Asp gene polymorphism and DN ri...

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Nitric oxide produced by endothelial nitric oxide synthase promotes diuresis.

Extracellular fluid volume is highly regulated, at least in part, by peripheral resistance and renal function. Nitric oxide (NO) produced by NO synthase type 3 (NOS 3) in the nonrenal vasculature may promote fluid retention by reducing systemic vascular resistance and arterial pressure. In contrast, NO produced by renal NOS 3 promotes water excretion by reducing renal vascular resistance, incre...

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Endothelial nitric oxide synthase and heart rate.

tables or figures and should relate solely to an article published in Circulation within the preceding 12 weeks. Authors of letters selected for publication will receive prepublication proofs, and authors of the article cited in the letter will be invited to reply. Replies must be signed by all authors listed in the original publication. Please submit three typewritten, double-spaced copies of ...

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 2000

ISSN: 0008-6363

DOI: 10.1016/s0008-6363(00)00093-6